Rapid functional assay for the detection of multidrug-resistant cells using the fluorescent dye rhodamine 123.
نویسندگان
چکیده
To the Editor: Making use of the fluorescent properties of anthracyclines they described a rapid flow cytometric assay for the determination of intracellular daunorubicin (DNR) accumulation and retention. Such a technically simple assay may offer the possibility to predict Recently, Berman et all examined the effect of tamoxifen on two cell lines that display the multidrug-resistant (MDR) phenotype.
منابع مشابه
Rapid Functional Assay for the Detection of Multidrug-resistant Cells Using the Fluorescent Dye Rhodamine
To the Editor: Making use of the fluorescent properties of anthracyclines they described a rapid flow cytometric assay for the determination of intracellular daunorubicin (DNR) accumulation and retention. Such a technically simple assay may offer the possibility to predict Recently, Berman et all examined the effect of tamoxifen on two cell lines that display the multidrug-resistant (MDR) pheno...
متن کاملRapid Functional Assay for the Detection of Multidrug-resistant Cells Using the Fluorescent Dye Rhodamine
To the Editor: Making use of the fluorescent properties of anthracyclines they described a rapid flow cytometric assay for the determination of intracellular daunorubicin (DNR) accumulation and retention. Such a technically simple assay may offer the possibility to predict Recently, Berman et all examined the effect of tamoxifen on two cell lines that display the multidrug-resistant (MDR) pheno...
متن کاملRapid Functional Assay for the Detection of Multidrug-resistant Cells Using the Fluorescent Dye Rhodamine
To the Editor: Making use of the fluorescent properties of anthracyclines they described a rapid flow cytometric assay for the determination of intracellular daunorubicin (DNR) accumulation and retention. Such a technically simple assay may offer the possibility to predict Recently, Berman et all examined the effect of tamoxifen on two cell lines that display the multidrug-resistant (MDR) pheno...
متن کاملRapid Functional Assay for the Detection of Multidrug-resistant Cells Using the Fluorescent Dye Rhodamine
To the Editor: Making use of the fluorescent properties of anthracyclines they described a rapid flow cytometric assay for the determination of intracellular daunorubicin (DNR) accumulation and retention. Such a technically simple assay may offer the possibility to predict Recently, Berman et all examined the effect of tamoxifen on two cell lines that display the multidrug-resistant (MDR) pheno...
متن کاملSensitive and Specific Fluorescent Probes for Functional Analysis of the Three Major Types of Mammalian ABC Transporters
An underlying mechanism for multi drug resistance (MDR) is up-regulation of the transmembrane ATP-binding cassette (ABC) transporter proteins. ABC transporters also determine the general fate and effect of pharmaceutical agents in the body. The three major types of ABC transporters are MDR1 (P-gp, P-glycoprotein, ABCB1), MRP1/2 (ABCC1/2) and BCRP/MXR (ABCG2) proteins. Flow cytometry (FCM) allow...
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عنوان ژورنال:
- Blood
دوره 78 5 شماره
صفحات -
تاریخ انتشار 1991